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*                        warfarinPK3_project.mlxtran                           *
*                        February 18, 2018 at 20:08:24                         *
*                        Monolix version : 5.0.0                               *
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POPULATION PARAMETERS ESTIMATION _______________________________________________

Fixed Effects ----------------------------    se_lin    rse(%)    pvalue
ka_pop                         :       0.5                              
V_pop                          :      7.57      0.17      2.24          
beta_V_lw70                    :     0.809    0.0952      11.8  <2.2e-16
Cl_pop                         :     0.135   0.00626      4.63          
beta_Cl_lw70                   :      0.61     0.246      40.3    0.0131

Standard Deviation of the Random Effects -
omega_ka                       :     0.818     0.189      23.1          
omega_Cl                       :     0.244    0.0349      14.3          

Error Model Parameters -------------------
a                              :     0.487    0.0917      18.8          
b                              :     0.108    0.0172      15.9          

Elapsed time (seconds) :      1.8
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CORRELATION MATRIX OF THE ESTIMATES ____________________________________________

Fisher by Linearization --------------------------------------------------------
Correlation Matrix :
       V_pop   1.00000
 beta_V_lw70   0.18056   1.00000
      Cl_pop   0.01198   0.01041   1.00000
beta_Cl_lw70   0.01054  -0.01103   0.08480   1.00000
    omega_ka   0.00000   0.00000   0.00000   0.00000   1.00000
    omega_Cl   0.00000   0.00000   0.00000   0.00000  -0.00974   1.00000
           a   0.00000   0.00000   0.00000   0.00000   0.02319  -0.04438   1.00000
           b   0.00000   0.00000   0.00000   0.00000  -0.04572   0.01677  -0.83627   1.00000
                               min       max   max/min
Eigen values           :      0.16       1.8        11

Elapsed time (seconds) :   0.007
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INDIVIDUAL PARAMETERS ESTIMATION _______________________________________________

Individual Parameters Estimation by Conditional Mode ---------------------------
           min        Q1    median        Q3       max
ka :      0.19      0.43     0.513     0.622      1.72
V  :      4.82      6.76       7.7      8.32      10.2
Cl :    0.0756     0.112      0.13     0.162     0.266

Elapsed time (seconds) :   0.011
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